Distinct neural correlates between suicide attempters with major depressive disorder and other psychiatric disorders: a multimodal imaging study
W.-S. Kim1, S. Odkhuu1, Y.M. Jae2, Y.-C. Chung1
1Jeonbuk National University, Psychiatry, Jeon-ju, Korea, Republic of, 2BongSeng Memorial Hospital, Psychiatry, Busan, Korea, Republic of
Background: Suicide attempters (SA) with mild diagnoses other than major depressive disorder (MDD) are underexplored.
Aims & Objectives: This study aimed to investigate neuroimaging abnormalities in SA with MDD (SA-MDD), SA with other psychiatric disorders (OPD) (SA-OPD), and healthy controls (HC) using MRI data. Associations between altered findings in the patient groups and anger, negative schema, or rumination were further examined.
Method: We recruited SA who visited the emergency department and divided them into two groups: SA-MDD (n=52) and SA-OPD (n=24). Age-, sex-, and education-matched HC) (n=100) participated in the study. Cortical thickness, surface area, and subcortical volume were measured using structural magnetic resonance imaging (MRI). Regional analysis and seed-based functional connectivity (FC) analyses were performed using resting-state functional MRI. Partial Pearson or Spearman correlation with psychological variables was conducted.
Results: Widespread decreases in cortical thickness and larger cortical surface areas in some regions were observed in both SA-MDD and SA-OPD. However, decreased hippocampal volume was observed only in SA-MDD. Altered FC was more prominent in SA-MDD than in SA-OPD. In addition, significant associations between altered seed-based FC and negative schema were observed in both groups. Importantly, the associations with anger and rumination were evident only in SA-OPD.
Discussion & Conclusions: These findings suggest that SA-OPD have similar alterations in brain morphometry to SA-MDD but show less prominent FC alterations. The clinical implications of anger and rumination in SA-OPD warrant further investigation.
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