¹Orygen, University of Melbourne, Melbourne, Australia, ²Swinburne University, Centre for Mental Health and Brain Sciences, Melbourne, Australia

Background: Clinical Trial Networks (CTNs) are common infrastructures for increasing the delivery of trials by widening the participation pool. CTNs also help to drive the research agenda by determining which trials are to be prioritised. We have recently developed a clinical trials network in the area of early psychosis in Australia. As part of this development an extensive scoping process was undertaken to determine the research priorities for the network.

Aims & Objectives: To undertake an extensive research scoping exercise to infrom the activities of the newly formed CTN.

Method: A multi-stage scoping process was undertaken with the three major stakeholder groups: the early psychosis lived experience community, early psychosis researchers and clinicians. For the last stage of the scoping process over 350 people ranked their research priorities. Almost equal numbers of the identified three stakeholder groups participated.

Results: The top priorities rated by all three groups were trials that aimed to improve long-term outcomes in early psychosis. The next three highly rated priorities were the treatment of negative symptoms, the treatment of trauma and treatment resistance. Further exploration of the meaning of term like long term outcome yielded different perspectives from clinicians and lived experience but both groups highlighted the importance of functional outcome measurement.

Discussion & Conclusions: An extensive research priority exercise has helped the newly formed CTN to focus efforts in particular areas. The CTN is currently supporting the development of 2 such "priority trials". It has also helped the consideration of composite outcome measures (such as desirability of outcome ranking approach) for clinical trails that include factors deemed important to long term outcomes, especially functional outcomes and quality of life.